The earth is seared, more and more turning into one enormous desert every day. The most privileged are living on artificial floating islands in the sky. As they are harvesting the clouds for their own needs, Francisco, a corn farmer, can no longer sustain his family on the ground. So he takes his remaining daughter Amelia and tries to take her to the spire: The gate to the promised land above the clouds.
In Cloud Chasers the player guides this little family through five deadly deserts and tries to gather as much water as possible to preserve their chances of survival.