No, you cannot edit your application form once it has been submitted. There is some leniency if your form has broken download links or expired coupon codes, and IndieCade staff will contact you if your entry has such. Additionally, should you be selected to showcase at any of our events, you are more than welcome to bring an updated build and provide new materials for media (screenshots, videos, copy, etc.).
If you are concerned about a bug in your submission or have made a major technical advance that may assist in the jurying of your game you may email firstname.lastname@example.org for consideration for updating your build, but there are no guarantees of accommodation of said build due to the fast nature of the jurying process.